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Synfacts 2010(2): 0202-0202  
DOI: 10.1055/s-0029-1219141
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Regio- and Stereoselective Hydrophosphin-ations Using Phosphine Borane Complexes

Contributor(s): Mark Lautens, David A. Candito
C. A. Busacca*, E. Farber, J. DeYoung, S. Campbell, N. C. Gonnella, N. Grinberg, N. Haddad, H. Lee, S. Ma, D. Reeves, S. Shen, C. H. Senanayake
Boehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, USA
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Publication History

Publication Date:
21 January 2010 (online)

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Significance

The authors report on the hydrophosphination of unactivated internal alkynes and allenyl phosphine oxides using phosphine borane complexes. The methodology represents a significant advancement to the scope of hydrophos­phinations employing such reagents. The authors also demonstrate the power of this methodology in the expedient synthesis of chiral mono- and bisphosphines which have important applications as ligands in asymmetric catalysis.