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Synfacts 2010(2): 0200-0200
DOI: 10.1055/s-0029-1219213
DOI: 10.1055/s-0029-1219213
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Enantioselective Direct Aldol Reactions Using Bifunctional Catalysis
Z. Xu, P. Daka, H. Wang*
Miami University, Oxford, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. Januar 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201002/lookinside/thumbnails/10.1055-s-0029-1219213-1.jpg)
Significance
Enamine catalysis has emerged as an extremely useful method for performing ‘direct’ aldol reactions (see Review below). Most of these catalysts contain secondary amines, and examples of highly enantioselective direct aldol reactions involving primary amines are rare. The authors have designed new chiral catalysts based on amino acids which utilize a primary amine as the Lewis basic site and a tightly bound metal as the Lewis acid site. These catalysts give high diastereo- and enantioselectivity in the direct aldol reaction of ketones with benzaldehydes.