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Synlett 2010(4): 667-674
DOI: 10.1055/s-0029-1219376
DOI: 10.1055/s-0029-1219376
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Fluorous Mixture Synthesis of Four Stereoisomers of the C21-C40 Fragment of Tetrafibricin
Further Information
Received
14 January 2010
Publication Date:
08 February 2010 (online)
Publication History
Publication Date:
08 February 2010 (online)
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Abstract
Four stereoisomers of the C21-C40 fragment are synthesized in a single exercise with the aid of fluorous tagging to encode configurations at C37 and C33. After demixing and detagging, the isomers were found to have substantially identical ¹H NMR spectra. However, there were some small but reliable differences in their ¹³C NMR spectra.
Key words
tetrafibricin - fibrinogen - fluorous mixture synthesis - quasiisomers - Kocienski-Julia reaction
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The column is available from Fluorous Technologies, Inc.
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D.P.C. owns an equity interest in this company.
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