Fluorous Mixture Synthesis of Four Stereoisomers of the C21-C40 Fragment of Tetrafibricin

Abstract

Four stereoisomers of the C21-C40 fragment are synthesized in a single exercise with the aid of fluorous tagging to encode configurations at C37 and C33. After demixing and detagging, the isomers were found to have substantially identical ^¹H NMR spectra. However, there were some small but reliable differences in their ^¹³C NMR spectra.

Key words

tetrafibricin - fibrinogen - fluorous mixture synthesis - quasiisomers - Kocienski-Julia reaction

References and Notes

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  The column is available from Fluorous Technologies, Inc.

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  D.P.C. owns an equity interest in this company.

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