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Synfacts 2010(4): 0377-0377  
DOI: 10.1055/s-0029-1219453
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Eudesmane Terpenes by C-H Activation

Contributor(s): Steven V. Ley, Philippa B. Cranwell
K. Chen, P. S. Baran*
The Scripps Research Institute, La Jolla, USA
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Publikationsdatum:
22. März 2010 (online)

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Significance

The biomimetic synthesis of five ­oxidized members of the eudesmane family of ­terpenes has been achieved using chemoselective principles. Strain release, steric, and electronic properties were used to discriminate between different C-H environments for intermolecular oxidation.