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Synfacts 2010(4): 0487-0487  
DOI: 10.1055/s-0029-1219460
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

A Mesoporous Silica-Supported Ruthenium Catalyst for Metathesis

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Chung Keun Jin
J. Lim, S. S. Lee*, J. Y. Ying*
Institute of Bioengineering and Nanotechnology, The Nanos, Singapore
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Publication History

Publication Date:
22 March 2010 (online)

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Significance

A mesoporous silica-supported catalyst 6 for metathesis was prepared and applied to a circulating flow reactor system. Thus, the Grubbs II catalyst was immobilized on siliceous mesocellular foam (MCF) microparticles 5 to give the catalyst 6. The ring-closing metathesis of dienes 7-12 was performed in a circulating flow reactor system filled with 6 (225 mg; reactor size = 4.6 mm x 50 mm) at 50 ˚C with a flow rate of 5 mL/min to afford the corresponding products 13-18 in 93-99% yield.