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Synfacts 2010(4): 0478-0478  
DOI: 10.1055/s-0029-1219513
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Additions to α,β-Unsaturated Acyl Phosphonates

Contributor(s): Benjamin List, Ilija Čorić
H. Jiang, M. W. Paixão, D. Monge, K. A. Jørgensen*
Aarhus University, Denmark
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Publikationsverlauf

Publikationsdatum:
22. März 2010 (online)

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Significance

Jørgensen and co-workers demonstrated the potential of unsaturated acyl phosphonates 4 as hydrogen-bond acceptors in enantio­selective organocatalysis. By employing chiral thioureas 1 and 2 or squaramide 3 as catalysts, with different carbon-based nucleophiles (5-7), products 8-10 were obtained in moderate to good yields and high enantioselectivity.