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Synfacts 2010(4): 0437-0437  
DOI: 10.1055/s-0029-1219616
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Metal-Controlled Reversal of Enantio-selectivity in the Alkylation of Indoles

Contributor(s): Hisashi Yamamoto, Patrick Brady
Y. Liu, D. Shang, X. Zhou, Y. Zhu, L. Lin, X. Liu, X. Feng*
Sichuan University, Chengdu, P. R. of China
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Publikationsdatum:
22. März 2010 (online)

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Significance

The catalytic system described ­allows efficient access to chiral building blocks, such as tryptophan derivatives. Slight modification of the ligand and changing the metal center allows for reversal of enantioselectivity with impressive yields and high ee values.