Download PDF
Synfacts 2010(4): 0441-0441  
DOI: 10.1055/s-0029-1219624
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Zn(II) Complexes Catalyzed Asymmetric Friedel-Crafts Alkylation of Pyrroles

Contributor(s): Hisashi Yamamoto, Zhi Li
P. K. Singh, V. K. Singh*
Indian Institute of Technology, Kanpur and Indian Institute of Science Education and Research, Bhopal, India
Further Information

Publication History

Publication Date:
22 March 2010 (online)

    Permissions and Reprints

Significance

In this paper, the authors developed a very efficient catalyst for the enantioselective Friedel-Crafts alkylation of pyrroles with 2-enoylpyridine N-oxides. The alkylation products are obtained in high yields and high enantioselectivities. Electron-rich furan and benzene derivatives also undergo this Friedel-Crafts reaction with high yield and enantioselectivity.