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Synfacts 2010(5): 0554-0554  
DOI: 10.1055/s-0029-1219638
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed Asymmetric Hydrogenation of Benzophenone N-H Imines

Contributor(s): Hisashi Yamamoto, Jiajing Tan
G. Hou, R. Tan, Y. Sun, X. Zhang*, F. Gosselin*
Merck Research Laboratories, Rahway and Rutgers, The State University of New Jersey, Piscataway, USA
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Publication History

Publication Date:
22 April 2010 (online)

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Significance

The authors presented a direct, protection-free approach to the synthesis of chiral diarylmethylamines by asymmetric hydrogenation of benzophenone N-H imines. By using commercially accessible, low-cost chiral monodentate phosphoramidite ligands, chiral diarylmethylamine derivates were obtained with high yield and enantioselectivity.