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Synfacts 2010(5): 0589-0589
DOI: 10.1055/s-0029-1219661
DOI: 10.1055/s-0029-1219661
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Dehydrative Pd/Cu-Catalyzed Coupling of Heterocycles with Terminal Alkynes
F.-A. Kang*, J. C. Lanter, C. Cai, Z. Sui, W. V. Murray
Johnson & Johnson Pharmaceutical Research and Development, Spring House, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. April 2010 (online)
Significance
The first chemoselective direct dehydrative cross-coupling of tautomerizable heterocycles with terminal alkynes via bimetallic Pd/Cu catalysis is reported. It uses readily available starting materials and is efficient for a number of various N-heterocycles and alkynes being especially suitable for substrates with sensitive groups.