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Synfacts 2010(5): 0567-0567  
DOI: 10.1055/s-0029-1219672
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rh-Catalyzed Regio- and Diastereoselective Hydroformylation of Bishomoallylic Alcohols

Contributor(s): Hisashi Yamamoto, Zhi Li
C. U. Grünanger, B. Breit*
Albert-Ludwigs-Universität Freiburg, Germany
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Publication History

Publication Date:
22 April 2010 (online)

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Significance

This report describes the most recent advance in catalytic branch-selective hydroformylation of alkenes. In addition to homoallylic alcohols that had been previously realized as substrates (Angew. Chem. Int. Ed. 2008, 47, 7346), bishomoallylic alcohols were subjected to the same reaction conditions and provided δ-lactols in high regioselectivity.