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Synfacts 2010(5): 0605-0605
DOI: 10.1055/s-0029-1219736
DOI: 10.1055/s-0029-1219736
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
A Chiral Ionene for Asymmetric Benzylation
S. Itsuno*, D. K. Paul, M. Ishimoto, N. Haraguchi
Toyohashi University of Technology, Japan
Further Information
Publication History
Publication Date:
22 April 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201005/lookinside/thumbnails/10.1055-s-0029-1219736-1.jpg)
Significance
An ionene of a cinchonidine derivative was prepared and applied to an asymmetric benzylation. Thus, the reaction of N-diphenylmethylidene glycine t-butyl ester with benzyl bromide was carried out with the ionene to give (S)-N-(diphenylmethylene)phenylalanine t-butyl ester in 83% yield with 86% ee (one example).