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Synfacts 2010(5): 0614-0614  
DOI: 10.1055/s-0029-1219740
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-SiO2@Fe3O4: A Catalyst for Cross-Coupling of Aryl Chlorides

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
M.-J. Jin*, D.-H. Lee
Inha University, Incheon, Korea
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Publication History

Publication Date:
22 April 2010 (online)

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Significance

A palladium complex bearing a silyl­alkyl chain unit was anchored onto silica-coated Fe3O4 particle (eq. 1). Pd-SiO2@Fe3O4 catalyzed the ­Suzuki, Sonogashira, and Stille couplings of aryl chlorides 1 with arylboronic acids 2, terminal alkynes 3, and organostannanes 4 to give the corresponding coupling products 5 (18 examples, 71-95% yield), 6 (18 examples, 74-95% yield), and 7 (18 examples, 72-96% yield), respectively.