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Synfacts 2010(5): 0595-0595
DOI: 10.1055/s-0029-1219744
DOI: 10.1055/s-0029-1219744
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Aza-Morita-Baylis-Hillman Reaction Using Aliphatic Imine Precursors
N. Abermil, G. Masson*, J. Zhu*
Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. April 2010 (online)
Significance
The authors report an enantioselective aza-Morita-Baylis-Hillman (MBH) reaction using aliphatic α-amidosulfones as imine precursors. In general, aliphatic imines are challenging substrates for the MBH reaction due to their side reactions. To avoid this problem the imine was generated in situ, and the products were obtained in good to excellent yields and high enantioselectivities.