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Synfacts 2010(5): 0592-0592
DOI: 10.1055/s-0029-1219754
DOI: 10.1055/s-0029-1219754
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Sulfa-Michael Addition Catalyzed by a Quinine-Derived Urea Catalyst
N. K. Rana, S. Selvakumar, V. K. Singh
Indian Institute of Technology, Kanpur and Indian Institute of Science Education and Research Bhopal, Govindpura, India
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. April 2010 (online)
Significance
A highly enantioselective sulfa-Michael addition between aromatic thiols and cyclic and acyclic enones promoted by a quinine-derived urea catalyst is reported. A remarkably low catalyst loading is used (0.1 mol). The authors suggest a transition state model.
Review: D. Enders, K. Lüttgen, A. A. Narine Synthesis 2007, 959-980.