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Synfacts 2010(7): 0745-0745
DOI: 10.1055/s-0029-1220019
DOI: 10.1055/s-0029-1220019
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Zolpidem
N. Chernyak, V. Gevorgyan*
University of Illinois at Chicago, USA
Further Information
Publication History
Publication Date:
22 June 2010 (online)
Significance
Zolpidem is a widely prescribed hypnotic for the short-term treatment of insomnia. It acts by binding to GABAA receptors at the same location as benzodiazepines. Alpidem, an anxiolytic drug that has been withdrawn from the market owing to liver damage, was also synthesized by the same route.