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Synfacts 2010(7): 0827-0827
DOI: 10.1055/s-0029-1220118
DOI: 10.1055/s-0029-1220118
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
The Influence of Chiral Solvents in Proline Catalysis
M. North*, P. Villuendas
Newcastle University, Newcastle upon Tyne, UK
Further Information
Publication History
Publication Date:
22 June 2010 (online)
Significance
The proline-catalyzed aldol reactions of aromatic aldehydes with different ketones and the influence of optically pure propylene carbonate 2 as solvent were investigated. The configuration of the catalyst and the solvent played a role, since among the possible combinations (R,R) proved to be a matched pair. The incorporation of these matched or mismatched pairs was investigated for various examples of the reported reaction. The products obtained exhibited pronounced differences in yields and enantioselectivities.