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Synfacts 2010(8): 0917-0917  
DOI: 10.1055/s-0030-1257814
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Valine-Derived Ruthenium Complex for Catalytic Metathesis Desymmetrization

Contributor(s): Hisashi Yamamoto, Patrick Brady
S. Tiede, A. Berger, D. Schlesiger, D. Rost, A. Lühl, S. Blechert*
Technische Universität Berlin, Germany
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Publication History

Publication Date:
22 July 2010 (online)

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Significance

The newly described chiral meta­thesis catalyst displays high reactivity and selectivity, in many cases surpassing that of chiral 3,4-disubstituted ligands. Remarkably, the catalyst loading can be lowered to 0.05 mol% without significantly diminishing conversion or ee.