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Synfacts 2010(9): 0971-0971  
DOI: 10.1055/s-0030-1257880
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of R207910

Contributor(s): Philip Kocienski
Y. Saga, R. Motoki, S. Makino, Y. Shimizu, M. Kanai*, M. Shibasaki*
The University of Tokyo, Japan
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Publication History

Publication Date:
23 August 2010 (online)

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Significance

R207910 is a selective inhibitor of the ATP synthase proton pump of both drug-sensitive and drug-resistant Mycobacterium ­tuberculosis. The synthesis of R207910 depicted features two novel transformations: (1) a catalytic enantioselective proton migration using a bimetallic Y complex (A → C) and (2) a CuF-catalyzed dia­stereoselective allylation reaction (C → E).