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Synfacts 2010(9): 1045-1045  
DOI: 10.1055/s-0030-1257940
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper(II)-Catalyzed syn-Selective Henry Reaction

Contributor(s): Hisashi Yamamoto, Patrick Brady
L. Cheng, J. Dong, J. You, G. Gao*, J. Lan*
Sichuan University, Chengdu, P. R. of China
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Publication History

Publication Date:
23 August 2010 (online)

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Significance

The authors report a highly diastereo- and enantioselective Henry reaction of nitroethane with aromatic and aliphatic aldehydes. The bisimidazoline ligand outperforms conventional bisoxazoline ligands in both yield and selectivity.