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Synfacts 2010(9): 1087-1087
DOI: 10.1055/s-0030-1257982
DOI: 10.1055/s-0030-1257982
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Suzuki and Ullmann Reactions of Aryl Chlorides with a Nano-Palladium Catalyst
B. Yuan, Y. Pan, Y. Li*, B. Yin, H. Jiang*
South China University of Technology, Guangzhou, P. R. of China
Further Information
Publication History
Publication Date:
23 August 2010 (online)
Significance
MIL-101-supported nano-palladium catalyst Pd/MIL-101 was prepared by impregnation of Pd(NO3)2 into MIL-101 in DMF followed by treatment with H2 at 200 ˚C (eq. 1). Pd/MIL-101 catalyzed the Suzuki-Miyaura coupling of aryl chlorides 1 with phenylboronic acid in the presence of NaOMe and TBAB to give the corresponding biaryls 2 in up to 97% isolated yield (eq. 2, 4 examples). The Ullmann coupling of aryl chlorides 1 also proceeded in the presence of Pd/MIL-101, NaOMe, and TBAB to afford the corresponding homocoupling products 3 in up to 96% isolated yield (eq. 3, 4 examples).