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Synfacts 2010(9): 1022-1022  
DOI: 10.1055/s-0030-1257995
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-NHC Complexes-Catalyzed Asymmetric 1,4-Addition

Contributor(s): Hisashi Yamamoto, Jiajing Tan
Q. Xu, R. Zhang, T. Zhang, M. Shi*
East China University of Science and Technology, Shanghai and Shanghai Institute of Organic Chemistry, P. R. of China
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Publikationsverlauf

Publikationsdatum:
23. August 2010 (online)

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Significance

Expanding their work on the use of axially chiral bidentate NHC-Pd(II) complexes, this work demonstrates the 1,4-addition of arylboronic acids to 2,3-dihydro-4-pyridones. Various 2-aryl-4-piperidones were prepared in moderate to high yield and excellent enantioselectivity.