Cluster Preface: Stereoselective Synthesis of Stereogenic Quaternary Carbons: A Formidable Challenge and Remarkable Recent Progress

Abstract

The stereoselective synthesis of stereogenic quaternary carbons is a challenging task, with significant progress being registered only in the last few years. In this Synlett Cluster, the most recent developments are presented by experts in this field.

Key words

stereoselective synthesis - quaternary carbons - stereocenters

References and Notes

• 1a

  http://drugtopics.modernmedicine.com/drugtopics/data/articlestandard//drugtopics/192009/597083/article.pdf

• 1b

  http://www.chem.cornell.edu/jn96/docs/Top200BrandNameDrugsbyRetailDollarsin2008draft5.pdf

• Early reviews:
• 2a Fuji K. Chem. Rev.  1993,  93:  2037 
• 2b Corey EJ. Guzman-Perez A. Angew. Chem., Int. Ed.  1998,  37:  388 
• For recent reviews, see:
• 2c Trost BM. Jiang C. Synthesis  2006,  369 
• 2d Quaternary Stereocenters: Challenges and Solutions for Organic Synthesis   Christoffers J. Baro A. Eds.:  Wiley-VCH; Weinheim: 2005. 
• 2e Christoffers J. Baro A. Adv. Synth. Catal.  2005,  347:  1473 
• 2f Douglas CJ. Overman LE. Proc. Natl. Acad. Sci. U.S.A.  2004,  101:  5363 
• 3a Eder U. Sauer G. Weichert R. Angew. Chem., Int. Ed. Engl.  1971,  10:  496 
• 3b Hajos ZG. Parrish DR. J. Org. Chem.  1974,  39:  1615 
• 3c Hajos ZG. Parrish DR. Org. Synth.  1985,  63:  26 
• 4a Sato Y. Sodeoka M. Shibasaki M. J. Org. Chem.  1989,  54:  4738 
• 4b Carpenter NE. Kucera DJ. Overman LE. J. Org. Chem.  1989,  54:  5845 
• 5 Lebsack AD. Link JT. Overman LE. Stearns BA. J. Am. Chem. Soc.  2002,  124:  9008