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Synlett 2010(16): 2415-2420
DOI: 10.1055/s-0030-1258556
DOI: 10.1055/s-0030-1258556
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Rapid and Regioselective Hydrogenation of α,β-Unsaturated Ketones and Alkylidene Malonic Diesters Using Hantzsch Ester Catalyzed by Titanium Tetrachloride
Further Information
Received
2 July 2010
Publication Date:
03 September 2010 (online)
Publication History
Publication Date:
03 September 2010 (online)
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Abstract
A regioselective hydrogenation of α,β-unsaturated ketones and alkylidene malonic diesters using Hantzsch ester as the reducing agent and titanium tetrachloride as a catalyst is described. The short reaction times and mild reaction conditions are the advantages of this method.
Key words
hydrogen transfer - reduction - α,β-unsaturated ketone - alkylidene malonic diester - titanium tetrachloride
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