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Synfacts 2010(11): 1258-1258
DOI: 10.1055/s-0030-1258591
DOI: 10.1055/s-0030-1258591
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Addition to Isatins
R. Shintani*, K. Takatsu, T. Hayashi*
Kyoto University, Japan
Further Information
Publication History
Publication Date:
21 October 2010 (online)
Significance
The authors report on the copper-catalyzed asymmetric 1,2-addition of arylboronates to isatins employing chiral N-heterocyclic carbenes (NHCs) as the supporting ligands. The authors also provide insight into the likely intermediates involved in the catalytic cycle.