Synthesis of (-)-Virginiamycin M2

J. Wu; J. S. Panek

doi:10.1055/s-0030-1258711

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Synfacts 2010(11): 1219-1219
DOI: 10.1055/s-0030-1258711

Synthesis of Natural Products and Potential Drugs

Synthesis of (-)-Virginiamycin M₂

Contributor(s): Steven V. Ley, Philippa B. Cranwell
J. Wu, J. S. Panek*
Boston University, USA

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Publication History

Publication Date:
21 October 2010 (online)

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Significance

Virginiamycin M₂ is a naturally occurring antibiotic produced by Streptomyces. Derivatives of the virginiamycins display potent antibiotic activity against methicillin-, erythromycin-, and vancomycin-resistant S. aureus and have led to drugs which have been used to treat severe Gram-positive bacterial infections.