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Synfacts 2010(11): 1283-1283
DOI: 10.1055/s-0030-1258723
DOI: 10.1055/s-0030-1258723
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Pd-Catalyzed γ-Arylation of α,β-Unsaturated Esters from Silyl Ketene Acetals
D. S. Huang, J. F. Hartwig*
University of Illinois at Urbana-Champaign, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. Oktober 2010 (online)
Significance
Herein, a new γ-selective arylation of α,β-unsaturated esters is reported by coupling aryl, heteroaryl or vinyl halides with the corrsponding silicon dienolates. The procedure tolerates reactive functional groups and proceeds in high yields even for sterically challenging substrates. The products are valuable compounds only available in multi-step sequences by conventional methods.