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Synfacts 2010(11): 1297-1297  
DOI: 10.1055/s-0030-1258726
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Cobalt-Catalyzed C-SMe Bond Activation of Heteroaromatic Thioethers

Contributor(s): Paul Knochel, Andreas J. Wagner
J.-M. Begouin, M. Rivard, C. Gosmini*
École Polytechnique, Palaiseau and Université Paris-Est, Créteil, France
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Publication History

Publication Date:
21 October 2010 (online)

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Significance

N-Heterocycles bearing methylthio substituents can be activated by CoBr2, enabling cross-coupling reactions as electrophiles with aryl or benzylzinc reagents. At the same time, the ­reaction conditions allow the generation of hetero-aryl-ZnSMe compounds that can be used as nucleophiles for subsequent cross-couplings.