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Synfacts 2010(11): 1229-1229  
DOI: 10.1055/s-0030-1258758
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart ˙ New York

Indium-Mediated Multicomponent Synthesis of Pyrroles

Contributor(s): Victor Snieckus, Johnathan Board
M. Lin*, L. Hao, R.-d. Ma, Z.-p. Zhan
Xiamen University, P. R. of China
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Publication History

Publication Date:
21 October 2010 (online)

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Significance

Reported is the indium trichloride mediated multicomponent synthesis of highly substituted pyrroles. The reaction proceeds in one pot and does not require the exclusion of air or moisture. A number of catalysts were investigated and indium trichloride was shown to be superior, although a mixture of Ag(OTf) and Cu(OTf)2 was also efficacious. Under the reaction conditions a terminal acetylenic TMS group is cleaved. This work is an extension of a previous method from the same group for the formation of furans.