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Synfacts 2010(11): 1301-1301  
DOI: 10.1055/s-0030-1258780
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Cinchona Alkaloid Squaramide Catalyzed Sulfa-Michael Addition

Contributor(s): Benjamin List, Anna Lee
L. Dai, S.-X. Wang, F.-E. Chen*
Fudan University, Shanghai, P. R. of China
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Publication History

Publication Date:
21 October 2010 (online)

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Significance

An efficient cinchona alkaloid squaramide catalyzed asymmetric sulfa-Michael conjugate addition of thiols to trans-chalcones is described. Chen and co-workers applied the cinchona squaramide catalyst developed by Rawal’s group (J. P. Malerich, K. Hagihara, V. H. Rawal J. Am. Chem. Soc. 2008, 130, 14416) to sulfa-Michael reactions and the products were obtained in moderate to good yields as well as moderate to high enantioselectivities under mild reaction conditions.