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Synfacts 2010(11): 1304-1304
DOI: 10.1055/s-0030-1258787
DOI: 10.1055/s-0030-1258787
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Highly Efficient Kinetic Resolution of Racemic Carboxylic Acids
I. Shiina*, K. Nakata, K. Ono, Y.-s. Onda, M. Itagaki
Tokyo University of Science and Sumitomo Chemical Co., Osaka, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. Oktober 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201011/lookinside/thumbnails/10.1055-s-0030-1258787-1.jpg)
Significance
Shiina and co-workers report a highy efficient kinetic resolution of racemic α-aryl-alkanoic acids using acyl transfer Birman catalyst 1 (V. B. Birman, X. Li Org. Lett. 2006, 8, 1351) to afford optically enriched esters utilizing achiral alcohols (s-factor: up to 484). The obtained bis-(α-naphthyl)-methyl esters could be easily transformed into the corresponding chiral acids, such as ibuprofen and naproxen, without loss of optical purity.