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Synfacts 2010(11): 1317-1317
DOI: 10.1055/s-0030-1258827
DOI: 10.1055/s-0030-1258827
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Water-Soluble Palladium Nanoparticles for the Suzuki Cross-Coupling
N. Mejías, R. Pleixats*, A. Shafir*, M. Medio-Simón, G. Asensio
Universitat Autònoma de Barcelona and Universidad de Valencia, Spain
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. Oktober 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201011/lookinside/thumbnails/10.1055-s-0030-1258827-1.jpg)
Significance
The water-soluble palladium nanoparticle catalyst 4 was prepared from trialkyne 1 and PEG-supported azide 2 via click cycloaddition, which was used for the Suzuki-Miyaura cross-coupling. Thus, the cross-coupling of iodo-, bromo-, and chloroarenes 5 (0.3 mmol) and arylboronic acids 6 (0.45 mmol) was performed with the catalyst 4 (0.25 mol%) and K2CO3 (0.75 mmol) to give the corresponding biaryl and teraryl compounds 7 in 16-99% yield (22 examples).