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Synfacts 2011(2): 0130-0130  
DOI: 10.1055/s-0030-1259213
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Zanamivir Congeners

Contributor(s): Philip Kocienski
J.-F. Soulé, A. Mathieu, S. Norsikian*, J.-M. Beau*
Institut de Chimie des Substances Naturelles, Gif-sur-Yvette and Université Paris-Sud, Orsay, France
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Publikationsverlauf

Publikationsdatum:
19. Januar 2011 (online)

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Significance

A series of zanamivir-oseltamavir hybrid analogues was prepared in good yield on a small scale using a three-component Petasis-Mannich reaction and an iron(III) chloride mediated cyclization.