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Synfacts 2011(2): 0121-0121  
DOI: 10.1055/s-0030-1259215
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Total Synthesis of (+)-Roxaticin

Contributor(s): Steven V. Ley, Catherine F. Carter
S. B. Han, A. Hassan, I. S. Ku, M. J. Krische*
University of Texas at Austin, USA
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Publication History

Publication Date:
19 January 2011 (online)

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Significance

The oxo-polyene macrolide (+)-ro­xaticin has been a popular target for the synthetic community. This synthesis requires only 20 steps and is particularly efficient due to a lack of chiral auxiliary controlled reactions and redox manipulations.