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Synfacts 2011(2): 0125-0125  
DOI: 10.1055/s-0030-1259218
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Lycoflexine

Contributor(s): Steven V. Ley, Sean Newton
J. Ramharter*, H. Weinstabl, J. Mulzer
Universität Wien, Austria
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Publication History

Publication Date:
19 January 2011 (online)

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Significance

(+)-Lycoflexine was first isolated in 1973 and belongs to the Lycopodium alkaloid family. The tetracyclic structure contains four ­carbogenic stereocenters, two of which are ­quaternary. This principal total synthesis of (+)-lycoflexine was accomplished over eight steps and an overall yield of 13%.