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Synfacts 2011(2): 0195-0195  
DOI: 10.1055/s-0030-1259233
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Stereospecific Cross-Coupling of Secondary Alkyl Trifluoroborates

Contributor(s): Paul Knochel, Tobias Thaler
D. L. Sandrock, L. Jean-Gérard, C.-y. Chen, S. D. Dreher, G. A. Molander*
University of Pennsylvania, Philadelphia and Merck Research Laboratories, Rahway, USA
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Publication History

Publication Date:
19 January 2011 (online)

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Significance

The cross-coupling of β-trifluoro­boratoamides was shown to proceed with high selectivity. Thereby, the carbonyl group of the amide moiety serves as a hemilabile ligand inhi­biting the undesired β-H-elimination pathway.