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Synfacts 2011(2): 0196-0196  
DOI: 10.1055/s-0030-1259234
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium(II)-Catalyzed Decarboxylative Addition of Benzoic Acids to Nitriles

Contributor(s): Paul Knochel, Tobias Thaler
J. Lindh, P. J. R. Sjöberg, M. Larhed*
Uppsala University, Sweden
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Publication History

Publication Date:
19 January 2011 (online)

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Significance

A novel palladium(II)-catalyzed ­synthesis of aryl ketones from ortho-substituted benzoic acids and nitriles has been developed. The method is general and can be applied to a broad range of substrates.