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Synfacts 2011(2): 0202-0202
DOI: 10.1055/s-0030-1259237
DOI: 10.1055/s-0030-1259237
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Palladium-Catalyzed Cyanation of Aryl Mesylates
P. Y. Yeung, C. M. So, C. P. Lau, F. Y. Kwong*
The Hong Kong Polytechnic University, P. R. of China
Further Information
Publication History
Publication Date:
19 January 2011 (online)
Significance
The first general palladium-catalyzed cyanation of aryl mesylates and tosylates is disclosed. The reaction proceeds under very mild conditions and tolerates functional groups, such as esters, ketones, and aldehydes. The use of water as solvent or co-solvent was found to be essential.