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Synfacts 2011(2): 0200-0200
DOI: 10.1055/s-0030-1259239
DOI: 10.1055/s-0030-1259239
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Coupling of Indium Homoenolates with Acid Chlorides
Z.-L. Shen, K. K. K. Goh, H.-L. Cheong, C. H. A. Wong, Y.-C. Lai, Y.-S. Yang, T.-P. Loh*
Nanyang Technological University, Singapore
Further Information
Publication History
Publication Date:
19 January 2011 (online)
Significance
In this work the preparation of water-tolerant indium homoenolates is reported. The reaction proceeds exclusively in aqueous solution by the oxidative addition of In/InCl3. The synthetic value of these homoenolates is shown in a palladium-catalyzed coupling with various acid chlorides, providing 1,4-dicarbonyl compounds in excellent yield.