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Synfacts 2011(2): 0199-0199  
DOI: 10.1055/s-0030-1259242
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

A Multiligand-Based Palladium Catalyst for C-N Cross-Coupling Reactions

Contributor(s): Paul Knochel, Andreas J. Wagner
B. P. Fors, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
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Publikationsdatum:
19. Januar 2011 (online)

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Significance

An alternative approach to the ­development of catalysts for C-N cross-coupling reactions is presented. The authors report a palladium catalyst based on two different biaryl-phosphine ligands, RuPhos and BrettPhos. By a ligand exchange reaction, this system takes the form of multiple catalysts, displaying the highest reactivity and substrate scope of all C-N cross-coupling systems which have been reported so far.