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Synfacts 2011(4): 0360-0360  
DOI: 10.1055/s-0030-1259589
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of a p38 MAP Kinase Inhibitor

Contributor(s): Philip Kocienski
R. R. Milburn et al.*
Amgen Inc, Thousand Oaks, USA
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Publication History

Publication Date:
18 March 2011 (online)

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Significance

The target p38 MAP kinase inhib­itor is a candidate for the treatment of various ­inflammatory disorders, such as rheumatoid ­arthritis, psoriasis and Crohn’s disease. It was synthesized on a multikilogram scale in eight steps from 2,6-difluoroaniline in 38% overall yield without recourse to chromatography.