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Synfacts 2011(4): 0422-0422  
DOI: 10.1055/s-0030-1259600
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Co-Catalyzed Cross-Coupling of C-H Bonds with Grignard Reagents

Contributor(s): Paul Knochel, Andreas K. Steib
B. Lin, Z.-H. Wu, Y.-F. Gu, C.-L. Sun, B.-Q. Wang*, Z.-J. Shi*
Peking University, Beijing, Shanghai Institute of Organic Chemistry and Nankai University, Tianjin, P. R. of China
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Publikationsdatum:
18. März 2011 (online)

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Significance

A highly regioselective cobalt-­catalyzed C-H transformation of benzo[h]-quinoline and phenylpyridine derivatives with ­Grignard reagents has been disclosed. The reaction proceeds at room temperature in the presence of TMEDA as ligand and 2,3-dichlorobutane as oxidant.