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Synfacts 2011(4): 0443-0443  
DOI: 10.1055/s-0030-1259617
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

A Cascade Annulation of Enals and Dienones

Contributor(s): Benjamin List, Ji-Woong Lee
X. Fang, K. Jiang, C. Xing, L. Hao, Y. R. Chi*
Nanyang Technological University, Singapore
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Publikationsverlauf

Publikationsdatum:
18. März 2011 (online)

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Significance

The authors describe a highly ­regio- and stereoselective cascade annulation of enals 1 and benzodi(enone)s 2 catalyzed by chiral NHCs. By controlling the electronic properties of the dienones, regioselective annulations of unsymmetrical dienones could also be achieved. The previously reported cyclopentene derivatives 5 were not detected (see also: V. Nair et al. J. Am. Chem. Soc. 2006, 128, 8736).