Download PDF
Synfacts 2011(4): 0414-0414  
DOI: 10.1055/s-0030-1259664
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Ketone Hydrogenation Catalyzed by Copper-Phosphine Complexes

Contributor(s): Hisashi Yamamoto, Zhi Li
K. Junge, B. Wendt, D. Addis, S. Zhou, S. Das, S. Fleischer, M. Beller*
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Germany
Further Information

Publication History

Publication Date:
18 March 2011 (online)

    Permissions and Reprints

Significance

This paper describes a highly ­reactive asymmetric hydrogenation of ketones catalyzed by copper-monodentate phosphine complexes. Since the cost of copper is much lower than other metal species commonly applied as hydrogenation catalyst, this reaction could be an excellent alternative to develop an economical and environmentally friendly asymmetric hydrogenation.