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Synfacts 2011(5): 0546-0546  
DOI: 10.1055/s-0030-1259772
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Mediated Trifluoromethylation of Heteroaromatic Iodides

Contributor(s): Paul Knochel, Thomas Kunz
C.-P. Zhang, Z.-L. Wang, Q.-Y. Chen, C.-T. Zhang, Y.-C. Gu, J.-C. Xiao*
Shanghai Institute of Organic Chemistry, P. R. of China
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Publikationsdatum:
15. April 2011 (online)

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Significance

This work discloses a protocol for the trifluoromethylation of aromatic and hetero­aromatic iodides under mild reaction conditions in excellent yield. The trifluoromethyl group is transferred from readily available (S)-(trifluoromethyl)-diphenyl sulfonium salts, whereby elemental copper acts as the reducing agent.