Indium-Catalyzed Reductive Alkylation of Indoles

Significance

Herein, an indium-catalyzed reductive alkylation of indoles is reported. The protocol tolerates a broad scope of functional groups and allows a flexible combination of indoles and alkynes affording alkylindoles in good yields. The preferred nucleophiles are hydrosilanes; however, carbon nucleophiles, such as trimethylsilyl cyanide or methoxythiophene, can also be used.