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Synfacts 2011(5): 0539-0539  
DOI: 10.1055/s-0030-1259778
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Free, Copper-Mediated Intermolecular Direct Biaryl Coupling

Contributor(s): Paul Knochel, Andreas J. Wagner
M. Kitahara, N. Umeda, K. Hirano*, T. Satoh, M. Miura*
Osaka University, Japan
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Publikationsdatum:
15. April 2011 (online)

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Significance

The copper-mediated intermolecular direct biaryl coupling of azoles and aryl azines is achieved without palladium catalysts. The reaction proceeds via dual C-H bond cleavage and provides access to a range of functionalized biaryl motifs.