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Synfacts 2011(5): 0470-0470  
DOI: 10.1055/s-0030-1259791
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Streptorubin B

Contributor(s): Steven V. Ley, Catherine F. Carter
D. X. Hu, M. D. Clift, K. E. Lazarski, R. J. Thompson*
Northwestern University, Evanston, USA
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Publication History

Publication Date:
15 April 2011 (online)

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Significance

Streptorubin B is a prodigiosin ­alkaloid that has been isolated as a red pigment from a strain of actinomycetes. The structure has been previously disputed due to the molecule’s complex atropisomerism, but the authors have determined the absolute and relative stereochemistry via X-ray crystallography and CD spectroscopy.