Synthesis of 3-Hydroxyphthalans via Oxa-Pictet-Spengler
Reaction

Z. Khorsandi; A. R. Khosropour; V. Mirkhani; I. M. Baltork; M. Moghadam; S. Tangestaninejad

doi:10.1055/s-0030-1259809

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Synfacts 2011(5): 0574-0574
DOI: 10.1055/s-0030-1259809

Polymer-Supported Synthesis

Synthesis of 3-Hydroxyphthalans via Oxa-Pictet-Spengler Reaction

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Shaheen M. Sarkar
Z. Khorsandi, A. R. Khosropour*, V. Mirkhani*, I. M. Baltork, M. Moghadam, S. Tangestaninejad
University of Isfahan, Isfaran, Iran

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Publikationsverlauf

Publikationsdatum:
15. April 2011 (online)

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Significance

Nanosilica sulfuric acid (NSSA) was prepared as a heterogeneous catalyst for the synthesis of 3-hydroxyphthalans via oxa-Pictet-Spengler reaction. Thus, the reaction of 3-hydroxybenzyl alcohols 1 and aromatic aldehydes 2 was carried out with NSSA under conventional heating and microwave irradiation conditions to give the corresponding 3-hydroxyphthalans 3 in 55-96% (heating) and 82-97% (microwave) yield.